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Table 9 also presents the incidence of adverse reactions occurring in at least 1% of pediatric patients topamax treated with TOPAMAX� and occurring with greater incidence than placebo . The most topamax commonly observed adverse reactions associated with the use of TOPAMAX� at dosages of 5 to 9 mg/kg/day in controlled trials in pediatric patients with partial onset seizures, primary generalized tonic-clonic seizures, or Lennox-Gastaut syndrome, that were seen at an incidence higher ( ? 5%) than in the placebo group were : fatigue, somnolence, anorexia, nervousness, difficulty with concentration/attention, difficulty with memory, aggressive reaction, and weight decrease (see Table 9) .
Table 12 shows adverse reactions from the adolescent pivotal trial (Study topamax 3 demonstrating the efficacy of TOPAMAX�; [see Clinical Studies]) in which there were 103 adolescent patients who were treated with placebo or 50 mg or 100 mg of TOPAMAX� and three predominantly adult trials in which there were 49 adolescent patients (12 to 17 years) who were treated with placebo or 50 mg, 100 mg or 200 mg of TOPAMAX� . Many topamax adverse reactions shown in Table 12 indicated a dose-dependent relationship . Table 12 also shows adverse reactions in adolescents in the controlled migraine trials when the incidence in a TOPAMAX� dose group was at least 5 % or higher than the incidence topamax of placebo . In four, fixed-dose, double-blind migraine prophylaxis clinical trials in topamax TOPAMAX�-treated adolescent patients, the most commonly observed adverse reactions associated with the use of 100 mg of TOPAMAX� that were seen at an incidence higher ( ? 5%) than in the placebo group were : paresthesia, upper respiratory tract infection, anorexia, and abdominal pain (see Table 12) .

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