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OPANA should be used during pregnancy only if the potential benefit justifies the potential risk In embryo-fetal developmental toxicity studies, pregnant rats and rabbits received oxymorphone hydrochloride at doses up to about 2 times (rats) and 8 times (rabbits) total human daily dose of 120 mg (based on body surface opana area) .
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4 times or rabbits that received less than 4 times the opana total human dose . There opana were no adverse developmental effects in rats that received 0 .

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