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In a small number of patients with mild to moderate hepatic impairment given single norvasc 20 mg norvasc drug card norvasc 0.5 mg norvasc package insert norvasc side effects in dose of 5 mg, amlodipine half-life has been prolonged (see ACTION AND CLINICAL PHARMACOLOGY, Pharmacokinetics) .
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Patients with severe hepatic impairment or hepatic failure: Because NORVASC is extensively metabolized by the liver and the plasma elimination half-life (t 1/2) is 56 hours in patients with impaired hepatic function, it should be administered cautiously and at reduced dosages in what type of drug is norvasc side effects of norvasc blood pressure medicine norvasc pfizer how long patients with severely impaired hepatic function (see DOSAGE AND ADMINISTRATION, Recommended Dose and Dosage Adjustment) .
norvasc Slow dose titration and careful monitoring are required in patients with severe hepatic impairment .
norvasc drug interactions define norvasc norvasc 10 mg uses norvasc pill how long does it take for Concomitant Use with Strong Inhibitors of CYP 3A4: Use of NORVASC with drugs that result in strong inhibition of CYP 3A4, such as ketoconazole, clarithromycin, ritonavir, may lead to increased plasma levels of amlodipine and associated serious events (see DRUG INTERACTIONS) .
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