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WHY IS IT IMPORTANT TO CALCULATE THE TOTAL DAILY morphine DOSAGE OF OPIOIDS? Dosages at or above 50 MME/day increase risks for overdose by at least Patients prescribed higher opioid dosages are at higher risk of overdose death .
In a national sample morphine rxlist morphine street name morphine hospice morphine t morphine how supplied morphine of Veterans Health Administration (VHA) patients with chronic pain receiving opioids from 2004–2009, patients who died of opioid overdose were prescribed an average of 98 MME/day, while other patients were prescribed an average Calculating the total daily dose of opioids helps identify patients who may benefit from closer monitoring, reduction or tapering of opioids, prescribing of naloxone, or other measures to reduce risk of overdose .
html morphine HOW SHOULD THE TOTAL DAILY DOSE OF OPIOIDS BE CALCULATED? DETERMINE the total daily amount of each opioid the patient takes . HOW MUCH IS 50 OR 90 MME/DAY FOR COMMONLY PRESCRIBED OPIOIDS? 50 mg of hydrocodone (10 tablets of hydrocodone/ acetaminophen morphine 5/300) 90 mg of hydrocodone (9 tablets of hydrocodone/ acetaminophen 10/325) 33 mg of oxycodone (~2 tablets of oxycodone sustained-release 15 mg) 60 mg of oxycodone (~2 tablets of oxycodone sustained-release 30 mg) 12 mg of methadone ( <3 tablets of methadone 5 mg) ~20 mg of methadone (4 tablets of methadone 5 mg) L E A R N M O R E | www .
CONVERT each to MMEs—multiply the dose for morphine each opioid by the conversion factor .
(see does morphine need to be refrigerated morphine per nebulizer morphine quantity morphine for end of table) ADD them together .
Calculating morphine milligram equivalents (MME) OPIOID (doses in mg/day except where morphine noted) CONVERSION FACTOR Fentanyl transdermal (in mcg/hr) These dose conversions are estimated and cannot account for all individual differences in genetics and pharmacokinetics .


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