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Effects on the Endocrine System Opioids inhibit the secretion hydrocodone of adrenocorticotropic hormone (ACTH), cortisol, and luteinizing hormone (LH) in humans [see ADVERSE REACTIONS] .
They also stimulate prolactin, growth hormone hydrocodone (GH) secretion, and pancreatic secretion of insulin and glucagon .
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The causal role of opioids in the syndrome of hypogonadism is unknown because the hydrocodone various medical, physical, lifestyle, and psychological stressors that may influence gonadal hormone levels have not been adequately controlled for in studies conducted to date [see ADVERSE REACTIONS] .
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Overall, hydrocodone the effects of opioids appear to be modestly immunosuppressive .


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