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difficile disease Renal: Interstitial nephritis PO: 250mg, 500mg capsules Powder for Suspension: 125mg/5mL, 187mg/5mL, 250 mg/5mL, 375mg/5mL Chewable tablets: 125mg, 187mg, 250mg, 375mg Extended release tablets: 375mg, 500mg Dosing in adults: Acute exacerbation of chronic bronchitis: 500 mg extendedrelease tablets PO q12h x 7 days Acute otitis media: 250mg to 500mg tablets PO q8h Lower respiratory tract infection: 250mg to 500mg tablets ceclor cefaclor ceclor cefaclor ceclor cefaclor ceclor cefaclor ceclor cefaclor ceclor cefaclor PO q8h Urinary tract infection: 250mg to 500mg tablets PO q8h Dosing in pediatrics: 20-40mg/kg divided PO q8h Disease state based dosing: Renal failure: Caution with markedly impaired renal function; dose adjustment for moderate to severe renal impairment not usually recommended Hepatic failure: No dosing changes recommended at this time .
Contraindications/Warnings/Precautions: Precautions: Hypersensitivity to penicillins, renal impairment Drug Interactions: Live Typhoid Vaccine: decreased immunological response to the typhoid vaccine ceclor cefaclor ceclor cefaclor ceclor cefaclor ceclor cefaclor ceclor cefaclor ceclor cefaclor Category B: No evidence of risk in humans but studies inadequate .
Monitoring Requirements: Therapeutic: Culture and sensitivities, serum levels, signs and symptoms of infection, white blood cell count Toxic: Urinalysis, BUN, SCr, AST and ALT, skin rash, Neutropenia and leukopenia, Prothrombin time in patients with renal or hepatic impairment or poor nutritional state, as well as patients receiving a protracted course of antimicrobial cefaclor therapy, and patients previously stabilized on anticoagulant therapy .
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