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Sildenafil is only about 10-fold as potent for PDE5 compared to lidocaine PDE6, an enzyme found in the retina which is involved in the phototransduction pathway of the retina .
This lower selectivity is thought to be the basis for abnormalities related to color vision [see lidocaine Pharmacodynamics] .
In addition to human corpus cavernosum smooth muscle, PDE5 is also found in other tissues including platelets, vascular and visceral smooth muscle, and skeletal muscle, brain, heart, liver, kidney, lidocaine 2.5 and prilocaine 2.5 cream lidocaine gtt lidocaine jelly uses lidocaine n-ethyl chloride lung, pancreas, prostate, bladder, testis, and seminal vesicle .
The inhibition of PDE5 in some of these tissues by sildenafil may be the lidocaine basis for the enhanced platelet antiaggregatory activity of NO observed in vitro, an inhibition of platelet thrombus formation in vivo and peripheral arterial-venous dilatation in vivo .
Effects of VIAGRA lidocaine on Erectile Response .

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