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The effects of cigarette smoking on zyban the pharmacokinetics of bupropion were studied in 34 healthy male and female volunteers; 17 were chronic cigarette smokers and 17 were nonsmokers .
Following oral administration of a single 150-mg dose of ZYBAN, there was no statistically significant difference in zyban Cmax, half-life, Tmax, AUC, or clearance of bupropion or its major metabolites between smokers and nonsmokers .
In a study comparing the treatment combination of ZYBAN and nicotine transdermal system (NTS) versus ZYBAN alone, no statistically significant differences were observed between the 2 treatment groups of combination ZYBAN and NTS (n = 197) and ZYBAN alone (n = 193) in the plasma concentrations of bupropion or its active metabolites at weeks 3 and zyban drug interactions zyban xl quit smoking medication zyban zyban uk zyban buy zyban generic name 6 .

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