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For cancer, methotrexate competitively inhibits dihydrofolate reductase (DHFR), an enzyme that participates in methotrexate the tetrahydrofolate synthesis . [28][29] does methotrexate cause nausea methotrexate cancer treatment methotrexate webmd methotrexate The affinity of methotrexate for DHFR is about 1000-fold that of folate .
[28] Folic acid is needed for the why is folic acid given with methotrexate methotrexate hair loss can you drink on methotrexate de novo synthesis of the nucleoside thymidine, required for DNA synthesis . DHFR catalyses the conversion of dihydrofolate to methotrexate the active tetrahydrofolate . [28] Also, folate is essential for what to avoid when taking methotrexate what is methotrexate used to treat side effects of injectable purine and pyrimidine base biosynthesis, so synthesis will be inhibited .

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