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Concomitant administration how lipitor works side effects of lipitor 20 mg what is lipitor made of is lipitor bad for your of LIPITOR with strong inhibitors of CYP 3A4 can lead to increases in plasma concentrations of atorvastatin . The extent of interaction and potentiation of effects depend on the variability lipitor of effect on CYP 3A4 . LIPITOR lipitor is metabolized by cytochrome P450 3A4 .
Therefore, in patients taking clarithromycin, caution should be used when the LIPITOR dose exceeds 20 mg [see WARNINGS AND PRECAUTIONS, Skeletal lipitor Muscle and DOSAGE AND ADMINISTRATION] . Atorvastatin AUC was significantly increased with concomitant administration of LIPITOR 80 mg with clarithromycin (500 mg lipitor twice daily) compared to that of LIPITOR alone [see CLINICAL PHARMACOLOGY] .

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