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Oxycodone was statistically significantly better than placebo on the primary efficacy tapentadol endpoint for the overall maintenance period using LOCF and PMI imputation, demonstrating assay sensitivity .
However tapentadol it was not statistically significantly superior at Week 12 .
The more conservative imputation methods (modified BOCF, BOCF and WOCF) resulted in tapentadol pain intensity outcomes that were statistically significantly worse than placebo .
These findings are a reflection tapentadol of the large number of oxycodone CR-treated subjects who discontinued the study .
The fact that the oxycodone comparator showed poor efficacy in the study raises concerns about the validity tapentadol fda approval tapentadol gc/ms nucynta klonopin nucynta better than hydrocodone nucynta of the study .
The secondary efficacy measure, responder analysis, indicated that the proportion of subjects with 50% improvement in the nucynta webmd nucynta label tapentadol fass tapentadol medscape nucynta uses tapentadol restless tapentadol SR group was statistically significantly greater (p=0 . 027) than tapentadol the response in the placebo group .
The percent of tapentadol SR subjects with 30% improvement in tapentadol SR was not tapentadol statistically significant (p=0 .
Oxycodone CR treatment was statistically significantly worse for all measures of tapentadol responders and this once again raises concerns about interpretation and validity of the results .


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