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Tolerance: Repeated tapentadol administration of opioids may lead to tolerance .
Tolerance is the need tapentadol for increasing doses of opioids to maintain a defined effect such as analgesia, in the absence of disease progression or other external factors .
tapentadol half life nucynta vs fentanyl nucynta er dosage strengths tapentadol tabletten nucynta 3% given oxycodone CR when assessed between 2 - 5 days after the last dose of study drug . Withdrawal tapentadol symptoms: In a study conducted over 12 months, 22 . 4% of patients given tapentadol PALEXIA® SR had objective signs of opioid withdrawal compared with 27 .

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