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Substances which raise blood pressure or induce a sodium and water retaining effect such as nonsteroidal anti-inflammatory drugs can clonidine reduce the therapeutic effect of clonidine .
Substances clonidine black box warning transdermal clonidine does clonidine block opiates does clonidine cause with 2-adrenergic receptor blocking properties, such as phentolamine, may abolish the 2-adrenergic receptor mediated effects of clonidine in a dose-dependent way .
Concomitant administration of drugs with a negative chronotropic or dromotropic effect such as -blockers or digitalis glycosides can cause or potentiate bradycardiac rhythm It cannot be ruled out that concomitant administration of a clonidine -blocker will cause or potentiate peripheral vascular disorders .

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