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The effectiveness of Trileptal as monotherapy for partial seizures in children aged 4-16 years was determined from data obtained in the studies described, as generic name for trileptal trileptal dosage for trigeminal neuralgia trileptal birth control does well as by pharmacokinetic/pharmacodynamic considerations .
Trileptal Monotherapy Trials Four randomized, controlled, double-blind, multicenter trials, conducted in a predominately adult population, demonstrated the efficacy of Trileptal as trileptal pediatric dosing trileptal oral suspension allergic reaction to trileptal trileptal low monotherapy .
Two trials compared Trileptal to placebo and two trials used a randomized withdrawal design to compare a high dose (2400 mg) with a low dose (300 mg) of Trileptal, after substituting Trileptal 2400 mg/day for one or more antiepileptic trileptal drugs (AEDs) .
All doses were trileptal administered on a twice-a-day schedule .
A fifth randomized, controlled, rater-blind, multicenter study, conducted in a pediatric population, trileptal failed to demonstrate a statistically significant difference between low and high dose Trileptal treatment groups .
One placebo-controlled trial was conducted in 102 patients (11-62 years of age) with refractory partial seizures who had trileptal completed an inpatient evaluation for epilepsy surgery .
Patients had been withdrawn from all AEDs and were required to have 2-10 partial seizures within 48 hours prior to trileptal randomization .
Patients were randomized to receive either placebo or Trileptal given as 1500 mg/day on Day 1 and 2400 mg/day thereafter for an additional nine days, or until one of the following three exit criteria occurred: 1) the trileptal occurrence of a fourth partial seizure, excluding Day 1, 2) two new-onset secondarily generalized seizures, where such seizures were not seen in the one-year period prior to randomization, or 3) occurrence of serial seizures or status epilepticus .


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